After narrowly escaping drug kingpin Alain Charnier, Jimmy "Popeye" Doyle is out for revenge. Taking his quest to his enemy's home turf, Doyle is determined to bring down Charnier's heroin ring. With Doyle's disregard for the "by the book" approach, he pursues Charnier with reckless abandon, until he is caught by Charnier's men. Doyle is held captive and forced to use heroin. After he is rescued and cured off the drug, Doyle finds out that he was set up by the French authorities in order to draw Charnier out of hiding. Now a complete loose cannon, Doyle will stop at nothing to make sure he brings the entire operation down.